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Revelation 8:1-13
Lamb opened the seventh seal. There was silence in heaven for about half an hour.
Seven angles who stand before God and seven trumpets were given to them.
Angle threw the censer and filled it with fire from the alter and threw it on the earth, there were peals of thunder, rumblings, flashes of lightning and an earthquake.
1st trumpet sound: 1/3 of the land was burned up.
2nd trumpet sound: 1/2 of the sea became blood and 1/3 of the living creature died.
3rd trumpet sound: 1/3 of river, lake became bitter, Wormwood.
4th trumpet sound: 1/3 of the sun, the moon and stars are darkened.
The first six judgement which follow the trumpet-blasts echo the plagues of Egypt recorded in Exodus 7-12
The trumpets which signal God's judgements parallel the seven seals, but the judgements are intensified.
The prayer of God's people play a significant part in all this.
The trumpets sound a note of warning.
The judgements, though severe, are not total.
They are intended to bring people  to their senses.
In symbolic picture-language John describes four calamities affecting the natural world - earth, sea, water and the heavens.
The woes of the lone eagle imply that there is worse to come. The remaining judgments directly affect humanity.
How?
Keep praying which play significant part in all this calamities.